PROS1 anticorps

N° du produit ABIN1108756

Cet anticorps Rat Monoclonal détecte spécifiquement PROS1 dans WB. Il présente une réactivité envers Humain.

Aperçu rapide pour PROS1 anticorps (ABIN1108756)

Antigène: PROS1 (PROS) (Protein S (PROS))

Reactivité: Humain

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp PROS1 est non-conjugé

Application: Western Blotting (WB)

Clone: PS7

Détail du produit anti-PROS1 anticorps

Specificité: Monoclonal antibody PS7 is specific for human Protein S (PS), a vitamin K-dependent plasma glycoprotein with a molecular weight of approximately 70 kDa. Allows specific detection of cells carrying PS by flow cytometry.

Réactivité croisée (Details): Species reactivity (tested):Human.

Purification: Affinity C Chromatography on Protein G

Isotype: IgG2a

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.1 mg/mL

Buffer: PBS, 0.02 % Sodium Azide, 0.1 % BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store undiluted at 2-8 °C.

Détails sur PROS1

Antigène: PROS1 (PROS) (Protein S (PROS))

Sujet: In humans, PS is mainly synthesized by hepatocytes. Mature PS has a modular structure consisting of a Gla-domain containing a short aromatic stack, a region sensitive to cleavage by thrombin and factor Xa , 4 epidermal growth factor (EGF)-like domains, and a sex hormone-binding globulin-like region. The biologic function of PS thought to be of primary importance is its ability to enhance Activated Protein C-dependent proteolytic inactivation of factors Va and VIIIa, which are respectively the cofactors in the pro-thrombinase and tenase complexes of the coagulation cascade. In this way, PS plays an important role in regulating thrombin generation, and therefore controlling procoagulant activity. Crucial to the APC-dependent functions of PS is the high-affinity interaction between PS and negatively charged phospholipid surfaces, conferred by calcium-induced folding of the amino-terminal Gla-domain.Synonyms: PROS, Vitamin K-dependent protein S

ID gène: 5627

NCBI Accession: NP_000304

UniProt: P07225